Lidocaine suppresses subthreshol oscillations by inhibiting persistance Na+ current in injured dorsal root ganglion neurons

Title:

Lidocaine suppresses subthreshol oscillations by inhibiting persistance Na+ current in injured dorsal root ganglion neurons

Creator:

Dong, H., Fan, Y.-H., Wang, Y.-Y., Wang, W.-T., and Hu, S.-J.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:497b3b12-6d53-474c-a314-9bf39a84118c
uuid:497b3b12-6d53-474c-a314-9bf39a84118c
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, neurovědy, neuropatická bolest, ganglia, neurosciences, neuropathic pain, lidocaine, dorsal root ganglion, etopic discharges, subtreshold membrane potential oscilations, persistant Na+ current, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The aim of this study was to determine the effect and mechanism of low concentration of lidocaine on subthreshold membrane potential oscillations (SMPO) and burst discharges in chronically compressed dorsal root ganglion (DRG) neurons. DRG neurons were isolated by enzymatic dissociation method. SMPO, burst discharges and single spike were elicited by whole cell patch-clamp technique in current clamp mode. Persistent Na+ current (INaP) and transient Na+ current (INaT) were elicited in voltage clamp mode. The results showed that SMPO was suppressed and burst discharges were eliminated by tetrodotoxin (TTX, 0.2 μ mol/l) in current clamp mode, INaP was blocked by 0.2 μ mol/l TTX in voltage clamp mode. SMPO, burst discharges and INaP were also suppressed by low concentration of lidocaine (10 μ mol/l) respectively. However, single spike and INaT could only be blocked by high concentration of lidocaine (5 mmol/l). From these results, it is suggested that INaP mediates the generation of SMPO in injured DRG neurons. Low concentration of lidocaine (10 μ mol/l) suppresses SMPO by selectively inhibiting INaP, but not INaT, in chronically compressed DRG neurons., H. Dong, Y.-H. Fan, Y.-Y. Wang, W.-T. Wang, S.J. Hu., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:4

Harvested from:

CDK

Metadata only:

false