Bone tissue as a systemic endocrine regulator

Title:

Bone tissue as a systemic endocrine regulator

Creator:

Ivana Žofková

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:49ca1bbd-6f03-4cb1-845d-651c2a2dcd6b
uuid:49ca1bbd-6f03-4cb1-845d-651c2a2dcd6b
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, inkretiny, testosteron, incretins, testosterone, bone morphogenetic peptide, angiotensin, osteocalcin, phosphatonins, phosphate homeostasis, FGF23, chronic kidney diseases, klotho-α, male reproduction, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Bone is a target tissue for hormones, such as the sex steroids, parathormon, vitamin D, calcitonin, glucocorticoids, and thyroid hormones. In the last decade, other “non-classic” hormones that modulate the bone tissue have been identified. While incretins (GIP and GLP-1) inhibit bone remodeling, angiotensin acts to promote remodeling. Bone morphogenetic protein (BMP) has also been found to have anabolic effects on the skeleton by activating bone formation during embryonic development, as well as in the postnatal period of life. Bone has also been identified as an endocrine tissue that produces a number of hormones, that bind to and modulate extra-skeletal receptors. Osteocalcin occupies a central position in this context. It can increase insulin secretion, insulin sensitivity and regulate metabolism of fatty acids. Moreover, osteocalcin also influences phosphate metabolism via osteocyte-derived FGF23 (which targets the kidneys and parathyroid glands to control phosphate reabsorption and metabolism of vitamin D). Finally, osteocalcin stimulates testosterone synthesis in Leydig cells and thus may play some role in male fertility. Further studies are necessary to confirm clinically important roles for skeletal tissue in systemic regulations., I. Zofkova., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2015 Volume:64 | Number:4

Harvested from:

CDK

Metadata only:

false