The assessment of plasma fatty acid profiles in newly diagnosed treatment-naïve paediatric Crohn’s disease

Title:

The assessment of plasma fatty acid profiles in newly diagnosed treatment-naïve paediatric Crohn’s disease

Creator:

Schwarz, Jan, Vecka, Marek, Stožický, František, Pomahačová, Renata, Staňková, Barbora, Tvrzická, Eva, Kreslová, Marcela, Zahálková, Romana, and Sýkora, Josef

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:4bbac4ee-3ba3-48e4-89ac-af650b4ba2a7
uuid:4bbac4ee-3ba3-48e4-89ac-af650b4ba2a7
issn:1802-9973
doi:10.33549/physiolres.934665

Subject:

děti, Crohnova nemoc, záněty, children, Crohn's disease, inflammations, polyunsaturated fatty acids, profiling, 14, and 612

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Fatty acid (FA) profiles as potentially relevant components of Crohn’s disease (CD) have been insufficiently analysed. We sought to explore the plasma profiles of n-3 and n-6 polyunsaturated fatty acids (PUFAs) in newly diagnosed untreated active CD. We included 26 consecutive CD pediatric patients (<19 years) and 14 healthy controls (HCs). Disease characteristics, including inflammatory markers, dietary histories, and the Pediatric Crohn’s Disease Activity Index (PCDAI), were obtained. The profiles of plasma FAs in plasma lipid classes were analysed by gas chromatography with FID detection of methyl esters. The erythrocyte sedimentation rate, C-reactive protein level and fecal calprotectin level (all p<0.001) were significantly higher in CD patients than in HCs. Most changes were observed in plasma phospholipids (PLs), such as a higher content of n-3 and changes in n-6 long-chain PUFAs in the CD group. The CD group had a lower ratio of n-6/n-3 PUFAs in PLs (p<0.001) and triacylglycerols (TAGs) (p<0.01). Correlations of the FA content in plasma PLs with disease activity scores of CD were also observed, which were positive for the sum of monounsaturated fatty acids (MUFAs) as well as oleic acid (18:1n-9) (both p<0.05). The metabolism of PUFAs is significantly altered even in treatment-naïve newly diagnosed active pediatric CD, and the content of major FAs in PLs correlates with disease activity and inflammatory markers, thus probably contributing to the still unclear early disease pathogenesis., Jan Schwarz, Marek Vecka, František Stožický, Renáta Pomahačová, Barbora Staňková, Eva Tvrzická, Marcela Kreslová, Romana Zahálková, Josef Sýkora., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

799-808

Source:

Physiological research | 2021 Volume:70 | Number:5

Harvested from:

CDK

Metadata only:

false