Parathyroid hormone response to vitamin D insufficiency in elderly males with chronic heart failure

Title:

Parathyroid hormone response to vitamin D insufficiency in elderly males with chronic heart failure

Creator:

Bozic, B., Loncar, G., Prodanovic, N., Lepic, T., Radojicic, Z., Cvorovic, V., Dimkovic, S., and Popovic, V.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:4bbd2357-165d-407b-b90b-3e6830902d9b
uuid:4bbd2357-165d-407b-b90b-3e6830902d9b

Subject:

Fyziologie člověka a srovnávací fyziologie, srdeční selhání, vitamin D, heart failure, PTH, response, vitamin D insufficiency, adiponectin, bone markers, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Secondary hyperparathyroidism (SHPT) may contribute to the systemic illness that accompanies chronic heart failure (CHF). Healthy elderly with vitamin D deficiency who did not develop hyperparathyroidism (functional hypoparathyroidism, FHPT) had lower mortality than those who di d. This study was designed to examine determinants of the PTH response in the vitamin D insufficient CHF patients. Sixty five vitamin D insufficient males with NYHA class II and III and 20 control subjects age ≥ 55 years were recruited. Echocardiography, physical performance, NT-pro-BNP, PTH, 25-hydroxyvitamin D (25(OH)D), adiponectin and bone activity surrogat e markers (OPG, RANKL, OC, β-CTx) were assessed. Increased NYHA cl ass was associated with SHPT, while physical performance was inferior compared to FHPT. SHPT was associated with lower left ventricular ejection fraction (LVEF) and flow mediated dilatation, but with higher left heart dimensions, left ventricular mass index and right ventricular systolic pressure. CHF patients with SHPT had increased NT-pro-BNP, adiponectin and bone markers, but decreased 25(OH)D compared to those with FHPT. Independent determinants for SHPT in CHF patients with vitamin D insufficiency were LVEF, adiponectin and β-CTx, irrespective of renal function and serum vitamin D levels. In conclusion, increased PTH levels, but not low vitamin D, demonstrated close relation to CHF severity., B. Bozic ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false