A mathematical model of rat ventricular cardiomyocyte with a novel description of intracellular and t-tubular Ca2+ dynamics

Title:

A mathematical model of rat ventricular cardiomyocyte with a novel description of intracellular and t-tubular Ca2+ dynamics

Creator:

Pásek, Michal and Šimurda, Jiří

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:4c973118-403c-45d2-a3c5-afeab267944b
uuid:4c973118-403c-45d2-a3c5-afeab267944b

Subject:

cardiac cell, intracellular Ca2+ dynamics, t-tubule, and quantitative modelling

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

In this paper, we present a novel quantitative description of intracellular and t-tubular Ca2+ dynamics in a model of rat cardiac ventricular myocyte. In order to simulate recently published data, the model incorporates t-tubular and peripheral dyads and intracellular subspaces, segmentation of the t-tubular luminal volume, reformulation of the inactivation properties of t-tubular land peripheral L-type calcium current (ICa) and a description of exogenous Ca2q+ buffer function in the intracellular space. The model is used to explore activity-induced changes of ion concentration in the intracellular and t-tubular spaces and their role in excitation - contraction coupling in ventricular myocytes. and Obsahuje Appendix se seznamy literatury, užitých zkratek a symbolů

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

471-480

Source:

Engineering mechanics: international journal for theoretical and applied mechanics | 2013 Volume:20 | Number:6

Harvested from:

CDK

Metadata only:

false