Long-term lisinopril dihydrate application decreases plasma noradrenaline but not adrenaline levels in chickens

Title:

Long-term lisinopril dihydrate application decreases plasma noradrenaline but not adrenaline levels in chickens

Creator:

Ozdemir, H. S., Aksulu, H. E., Farataş, F., Ustündag, B., and Bingöl, I.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:4deaa785-70c4-4d96-a159-e50116f8211c
uuid:4deaa785-70c4-4d96-a159-e50116f8211c
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, kuřata, krevní tlak, adrenalin, chickens, blood pressure, adrenaline, noradrenaline, lisinopril dihydrate, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Little is known about the effect of chronic angiotensin-converting enzyme inhibition on the catecholamine levels in fowls. In this study, we investigated the effects of chronic lisinopri1 dihydrate (Ld) application on the plasma levels of adrenaline and noradrenaline and on the blood pressure. Lisinopril was given in different concentrations (25, 75 and 250 mg/l drinking water) to the white Leghorn chickens for 9 weeks, while the control group drank tap water only. Twenty-eight hours after the last lisinopril application, arterial blood pressure (BP), plasma adrenaline and noradrenaline levels, plasma renin (PRA) and plasma angiotensin-converting enzyme (ACE) activities were determined. In all concentrations, lisinopril significantly increased PRA and decreased ACE activities. Arterial BP was decreased only in the group receiving high lisinopril concentration (Controls 119±10.27, Ld3 98±5.4 mm Hg). However, the lower lisinopril concentrations did not alter arterial BP compared to the control group. Plasma noradrenaline levels were decreased in a concentration-dependent manner (47-58 %), but plasma adrenaline levels remained unchanged. The heart weight/body weight ratio was not changed in any of the lisinopril-treated groups. The persistent decrease in the blood pressure after lisinopril treatment was not directly related to a decrease of plasma ACE activity or plasma noradrenaline levels. Its mechanism still remains to be elucidated., H. S. Ozdemir, H. E. Aksulu, F. Karataş, B. Ustündag, I. Bingöl., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2000 Volume:49 | Number:1

Harvested from:

CDK

Metadata only:

false