Cardioprotective properties of opioid receptor agonists in rats with stress-induced cardiac injury

Title:

Cardioprotective properties of opioid receptor agonists in rats with stress-induced cardiac injury

Creator:

Prokudina, E. S., Maslov, L. N., Naryzhnaya, N. V. , Tsibulnikov, S. Yu. , Lishmanov, Y. B., Madias, J. E. , and Oeltgen, P. R.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:4e8a7667-54f0-4196-a4c7-4cd5a7f9f9b8
uuid:4e8a7667-54f0-4196-a4c7-4cd5a7f9f9b8
doi:10.33549/physiolres.933946

Subject:

99mTc-pyrophosphate, opioid receptors, Tako-tsubo syndrome, stress, and cardiomyopathy

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

The objectives of this study were to investigate the role of endogenous opioids in the mediation of stress-induced cardiomyopathy (SIC), and to evaluate which opioid receptors regulate heart resistance to immobilization stress. Wistar rats were subjected to 24 h immobilization stress. Stress-induced heart injury was assessed by 99mTc-pyrophosphate accumulation in the heart. The opioid receptor (OR) antagonists (naltrexone, NxMB – naltrexone methyl bromide, MR 2266, ICI 174.864) and agonists (DALDA, DAMGO, DSLET, U-50,488) were administered intraperitoneally prior to immobilization and 12 h after the start of stress. In addition, the selective µ OR agonists PL017 and DAMGO were administered intracerebroventricularly prior to stress. Finally pretreatment with guanethidine was used. Naltrexone did not alter the cardiac 99mTc-PP accumulation in stressed rats. NxMB aggravated stress-induced cardiomyopathy (P=0.005) (SIC). The selective µ OR agonist DALDA, which does not cross the blood-brain barrier, completely prevented (P=0.006) SIC. The µ OR agonist DAMGO exhibited weaker effect than DALDA. The selective δ ligand (DSLET) and κ OR ligand (U-50,488) did not alter stress-induced 99mTc-pyrophosphate accumulation in the heart. Intracerebroventricular administration of the µ OR agonists aggravated SIC. Pretreatment with guanethidine abolished this effect (P=0.01). Guanethidine alone exhibited cardioprotective properties. A stimulation of central µ OR promotes an appearance of SIC. In contrast, stimulation of peripheral µ OR contributes to an increase in cardiac tolerance to stress

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

375-384

Source:

Physiological research | 2019 Volume:68 | Number:3

Harvested from:

CDK

Metadata only:

false