Acetaldehyde at clinically relevant concentrations inhibits inward rectifier potassium current IK1 in rat ventricular myocytes

Title:

Acetaldehyde at clinically relevant concentrations inhibits inward rectifier potassium current IK1 in rat ventricular myocytes

Creator:

Markéta Bébarová, Matejovič, P., Milena Šimurdová, and Jindřich Šimurda

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:4ecb40b4-72c0-4508-ad36-aabc4e23f06b
uuid:4ecb40b4-72c0-4508-ad36-aabc4e23f06b
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, acetaldehyd, acetaldehyde, arrhythmias, inward rectifier, IK1 inhibition, rat ventricular myocytes, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Considering the effects of alcohol on cardiac electrical behavior as well as the important role of the inward rectifier potassium current I K1 in arrhythmogenesis, this study was aimed at the effect of acetaldehyd e, the primary metabolite of ethanol, on I K1 in rat ventricular myocytes. Acetaldehyde induced a reversible inhibition of I K1 with IC 50 = 53.7± 7.7 μM at -110 mV; a significant inhibition was documented even at clinically -relevant concentrations (at 3 μM by 13.1 ±3.0 % ). The inhibition was voltage -independent at physiological voltages above - 90 mV. The I K1 changes under acetaldehyde may contribute to alcohol - induced alterations of cardiac electrophysiology, especially in individuals with a genetic defect of a ldehyde dehydrogenase where the acetaldehyde level may be elevated., M. Bébarová, P. Matejovič, M. Šimurdová, J. Šimurda., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2015 Volume:64 | Number:6

Harvested from:

CDK

Metadata only:

false