Hyperoxia blunts acute hypoxia- and PGF2α-induced pulmonary vasoconstriction in chronically hypoxic rats

Title:

Hyperoxia blunts acute hypoxia- and PGF2α-induced pulmonary vasoconstriction in chronically hypoxic rats

Creator:

Žaloudíková, Marie, Martin Vízek, and Jan Herget

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:50207b2f-c46c-4dc9-b935-760611c35609
uuid:50207b2f-c46c-4dc9-b935-760611c35609

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, hypoxie, hyperoxie, human physiology, hypoxia, hyperoxia, isolated pulmonary arteries, hypoxic pulmonary vasoconstriction, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

We investigated the influence of oxygenation of in vitro lung preparation on the pulmonary vascular reactivity. Small pulmonary vessels isolated from adult male Wistar rats exposed for 4 days to hypoxia (FiO2 = 0.1, group CH) were compared with those of normoxic controls (group N). The bath in the chamber of small vessel myograph was saturated with gas mixture containing either 21 % or 95 % of O2 with 5 % CO2 and we measured the reactions of vessels to acute hypoxic challenge with 0 % O2 or to PGF2α. We did not observe any difference of the contractile responses between both groups when the normoxic conditions were set in the bath. When the bath oxygenation was increased to 95 % O2, the contractions induced by hypoxic challenge and PGF2α decreased in chronically hypoxic rats and did not change in normoxic controls. We hypothesize that reduced reactivity of vessels from hypoxic rats in hyperoxia results from the effect of chronic hypoxia on Ca2+ signaling in the vascular smooth muscle, which is modulated by increased free radical production during the exposure to chronic hypoxia and further hyperoxia., M. Žaloudíková, M. Vízek, J. Herget., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2009 Volume:58 | Number:6

Harvested from:

CDK

Metadata only:

false