Cardiac morphofunctional characteristics of transgenic rats with overexpression of the bradykinin B1 receptor in the endothelium

Title:

Cardiac morphofunctional characteristics of transgenic rats with overexpression of the bradykinin B1 receptor in the endothelium

Creator:

Levy, R. F., Serra, A. J., Antonio, E. L., dos Santos, L., Bocalini, D. S., Pesquero, J. B., Bader, M., Merino, V. F., Oliveira, H. A. de, Arruda Veiga, E. C. de, Silva Jr., J. A., and Tucci, P. J. F.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:50a825a9-4cb9-4806-aad0-33a7d793e96c
uuid:50a825a9-4cb9-4806-aad0-33a7d793e96c

Subject:

bradykinin receptor, cardiac structure, cardiac function, myocardial function, and transgenic rat

Type:

article, model:article, and TEXT

Description:

Our aim was to evaluate whether endothelial overexpressing of the bradykinin B1 receptor could be associated with altered left ventricular and myocardial performance. Echocardiography and hemodynamic were employed to assess left ventricular morphology and function in Sprague Dawley transgenic rats overexpressing the endothelial bradykinin B1 receptor (Tie2B1 rats). The myocardial inotropism was evaluated on papillary muscles contracting in vitro. In Tie2B1 animals, an enlarged left ventricular cavity and lower fractional shortening coupled with a lower rate of pressure change values indicated depressed left ventricular performance. Papillary muscle mechanics revealed that both Tie2B1 and wild-type rat groups had the same contractile capacities under basal conditions; however, in transgenic animals, there was accentuated inotropism due to post-pause potentiation. Following treatment with the Arg9-BK agonist, Tie2B1 papillary muscles displayed a reduction in myocardial inotropism. Endothelial B1 receptor overexpression has expanded the LV cavity and worsened its function. There was an exacerbated response of papillary muscle in vitro to a prolonged resting pause, and the use of a B1 receptor agonist impairs myocardial inotropism.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2017 Volume:66 | Number:6

Harvested from:

CDK

Metadata only:

false