Hematological profile of untreated or ionizing radiation-exposed cyclooxygenase-2-deficient mice

Title:

Hematological profile of untreated or ionizing radiation-exposed cyclooxygenase-2-deficient mice

Creator:

Michal Hofer, Zuzana Hoferová, Ladislav Dušek, Karel Souček, and Gruzdev, A.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:519bfef0-230f-46f9-9dd7-0e59fb220957
uuid:519bfef0-230f-46f9-9dd7-0e59fb220957
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, cyklooxygenáza 2, krvetvorba, ionizující záření, cyclooxygenase 2, hematopoiesis, ionizing radiation, COX-2 knock-out mice, post-irradiation inflammation, 14, and 612

Type:

article, články, journal articles, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

We investigated hematopoiesis in untreated and ionizing radiation-exposed cyclooxygenase-2-deficient (COX-2 KO) mice. We performed a complex hematological analysis of 16 parameters in untreated COX-2 KO male mice or COX-2 KO male mice irradiated with the dose of 4 Gy of γ-rays and their wildtype littermates. At baseline, hematopoiesis was increased in COX-2-deficient mice, but attenuated by irradation in COX-2- deficient mice compared to wildtype. To conclude, the antiinflammatory action of the COX-2 genetic disruption plays a positive role in hematopoiesis under basal conditions but is detrimental following radiation exposure., M. Hofer, Z. Hoferová L. Dušek, K. Souček, A. Gruzdev., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2017 Volume:66 | Number:4

Harvested from:

CDK

Metadata only:

false