Imprinting of high sensitivity to a high-cholesterol diet by nutrition in early life

Title:

Imprinting of high sensitivity to a high-cholesterol diet by nutrition in early life

Creator:

Poledne, R. and Hajná, J.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:525c6de8-773c-45ad-8e5a-30e5666d9dab
uuid:525c6de8-773c-45ad-8e5a-30e5666d9dab

Subject:

cholesterol metabolism, cholesterol dietary, lipoproteins, child nutrition, and gene expression

Type:

article, model:article, and TEXT

Description:

Imprinting of an increased sensitivity to a high-fat, high cholesterol (HFHC) diet by dietary manipulation in early life was studied in two strains of rat, i.e. in Prague hereditary hypercholesterolaemic rats (PHHC) and Wistar rats, from which the PHHC strain was obtained by selection and inbreeding. Whereas no effect of early life nutrition on cholesterolaemia induced by HFHC diet was found in control Wistar rats, significant imprinting of increased sensitivity to the same diet was demonstrated in PHHC rats. This imprinting increased the concentration of apoB- containing lipoprotein and liver cholesterol concentration in animals fed HFHC diet for a period of two months after weaning. No effect of this imprinting on endogenous cholesterol synthesis could be demonstrated. It is concluded that imprinting of increased sensitivity to HFHC diet by dietary manipulation in early life is not a general phenomenon but depends on underlying genetic predisposition(s).

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1998 Volume:47 | Number:2

Harvested from:

CDK

Metadata only:

false