Effect of low calorie diet and controlled fasting on insulin sensitivity and glucose metabolism in obese patients with type 1 diabetes mellitus

Title:

Effect of low calorie diet and controlled fasting on insulin sensitivity and glucose metabolism in obese patients with type 1 diabetes mellitus

Creator:

František Musil, Alena Šmahelová, Vladimír Bláha, Radomír Hyšpler, Alena Tichá, Jiřina Lesná, Zdeněk Zadák, and Sobotka, L.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:52ae6fb2-121d-4e09-bb2d-e3a344d4aecc
uuid:52ae6fb2-121d-4e09-bb2d-e3a344d4aecc

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, type 1 diabetes mellitus, obesity, fasting, low calorie diet, insulin sensitivity, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

Obesity in T1DM patients is associated with the components of metabolic syndrome. The influence of controlled fasting and low calorie diet (LCD) on insulin sensitivity and glucose metabolism was studied in 14 obese patients with type 1 diabetes mellitus (T1DM) (42.6±9.4 years, BMI 32.4±2.1 kg m−2). Insulin sensitivity in obese T1DM patients was measured using a hyperinsulinemic-euglycemic clamp before fasting, immediately after 7 days of fasting, and after 21 days of LCD. Glucose oxidation and non-oxidative glucose disposal were measured before and during the clamp by indirect calorimetry. In the control group of 13 of non-obese T1DM patients (36.9±13.9 years, BMI 22.6±2.1 kg m−2), only one hyperinsulinemiceuglycemic clamp was performed. Obese T1DM patients lost 6.1±1.1 kg after fasting and maintained reduction in body weight after 21 days of LCD. Fasting transiently reduced insulinmediated glucose disposal in the clamp (from 9.69±1.48 to 6.78±1.21 mg min−1 kg−1, P<0.001). This was caused by reduced glucose oxidation after the fasting period (from 2.81±0.52 to 0.88±0.98 mg min−1 kg−1, P<0.001). We conclude that one week of fasting transiently decreased insulin-mediated glucose disposal in T1DM patients. This was caused by reduced glucose oxidation., F. Musil, ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2013 Volume:62 | Number:3

Harvested from:

CDK

Metadata only:

false