The effect of medetomidine-ketamine anesthesia on hemodynamic parameters during hemorrhagic shock in minipigs

Title:

The effect of medetomidine-ketamine anesthesia on hemodynamic parameters during hemorrhagic shock in minipigs

Creator:

Brezina, A., Tomáš Drábek, Hynek Říha, Jitka Schreiberová, and Ladislav Hess

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:53b2c42c-bcf5-4e9d-ad8b-e6a3f746116d
uuid:53b2c42c-bcf5-4e9d-ad8b-e6a3f746116d

Subject:

Fyziologie člověka a srovnávací fyziologie, ketamin, ketamine, hemorrhagic shock, alpha2-agonists, remifentanil, propofol, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Hemorrhagic shock (HS) represents an acute event with high mortality. The optimal combination of anesthetics that would prevent hemodynamic collapse and allow damage control surgery has not yet been determined. We tested the hypothesis that a combination of dissociative anesthetic ketamine with alpha2- agonist medetomidine (MK group, n=10) would provide superior hemodynamic control compared to propofol-remifentanil (PR group, n=10) during HS in minipigs. A modified Wiggers‘ model of HS with a target mean arterial pressure (MAP) of 40 mm Hg and 2 h duration was used. All minipigs survived. HS led to a ~50 % decrease in cardiac output in both groups (P<0.001 for baseline vs. HS 120 min) with no differences between groups. Total volume of removed blood was larger in the MK group (1321±133 ml vs. 1111±246 ml in the PR group, respectively; P<0.05). MAP was higher during the initial phases of HS in the MK group than in PR group (P<0.05 at HS 30-90 min). HR was lower in the MK group at the late phases of HS (P<0.05 at HS 60-120 min). In conclusion, medetomidine-ketamine provides a feasible and possibly a more favorable alternative to the propofol-remifentanil combination in our model of HS in minipigs., A. Brezina ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2010 Volume:59 | Number:5

Harvested from:

CDK

Metadata only:

false