Does Vigabatrin Possess an Anticonvulsant Action Against Pentylenetetrazol-Induced Seizures in Developing Rats?

Title:

Does Vigabatrin Possess an Anticonvulsant Action Against Pentylenetetrazol-Induced Seizures in Developing Rats?

Creator:

Renata Haugvicová, Hana Kubová, and Pavel Mareš

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:542b6650-40f5-40e3-8529-c5591ba57341
uuid:542b6650-40f5-40e3-8529-c5591ba57341
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, Vigabatrin, Pentylenetetrazol, Motor seizures, Ontogeny, Rat, 14, and 612

Type:

article, studie, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Anticonvulsant action of vigabatrin (300, 600, 900 and/or 1200 mg/kg i.p.), an inhibitor of GABA-transaminase, was studied in a model of motor sezures elicited by pentylenetetrazol. Five age groups of rats (7, 12, 18, 25 and 90 days old) received a s.c. injection of pentylenetetrazol 4, 6 and/or 24 hours after vigabatrin administration. The incidence of minimal, predominantly clonic seizures was not changed in any age group, but their latencies were prolonged in 18- and 25-day-old rats. Generalized tonic-clonic seizures were influenced in a more complex manner. Incidence of these seizures was decreased in 7-day-old rat pups 24 hours after vigabatrin administration. Higher doses of vigabatrin exhibited a similar effect in adult rats at all intervals studied. Specific suppression or at least restriction of the tonic phase was observed in all groups of immature rats, the effect was more marked 24 hours after vigabatrin than at shorter intervals. The anticonvulsant action of vigabatrin, which could be demonstrated mainly against generalized tonic-clonic seizures, varies markedly during development., R. Haugvicová, H. Kubová, P. Mareš., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2002 Volume:51 | Number:4

Harvested from:

CDK

Metadata only:

false