Common carotid wall shear stress and carotid atherosclerosis in end-stage renal disease patients

Title:

Common carotid wall shear stress and carotid atherosclerosis in end-stage renal disease patients

Creator:

Jan Malík, Kudlička, J., Vladimír Tuka, Eva Chytilová, Adamec, J., Ročínová, K., and Vladimír Tesař

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:565fb2c0-d66a-436e-b040-5e015da398c4
uuid:565fb2c0-d66a-436e-b040-5e015da398c4

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, atherosclerosis, dialysis, end-stage renal disease, wall shear stress, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

Decrease of arterial wall shear stress (WSS) is associated with higher probability of atherosclerotic plaque development in many disease conditions. End-stage renal diseases (ESRD) patients suffer from vascular disease frequently, but its nature differs from general population. This study was aimed at proving an association between common carotid wall shear stress and the presence of carotid bifurcation plaques in a group of ESRD patients. ESRD subjects, planned for the creation of a dialysis access and therapy were included. Wall shear rate (WSR) was used as a surrogate of WSS and was analyzed in the common carotid arteries by duplex ultrasonography. Intima media thickness (IMT) was measured at the same site. The presence/absence of carotid bifurcation plaques was recorded. The endothelial function was estimated by the levels of von Willebrand factor (vWf). 35 ESRD patients were included (19 females, 17 diabetics). Atherosclerotic plaque was present in 53 % of bifurcations. Wall shear rate was lower in arteries with plaques (349±148 vs. 506±206 s-1, p=0.005) and was directly related to the height of IMT and inversely to the activity of vWf (r= –0.65, p=0.016). Lower wall shear rate in the common carotid arteries is linked to the endothelial dysfunction and to the presence of atherosclerotic plaques in carotid bifurcations in ESRD subjects. Faster arterial dilatation may facilitate this process in ESRD subjects., J. Malík ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2012 Volume:61 | Number:4

Harvested from:

CDK

Metadata only:

false