The action of pramiracetam on consequences of hypobaric hypoxia is only moderate

Title:

The action of pramiracetam on consequences of hypobaric hypoxia is only moderate

Creator:

Marešová, D. and Mareš, P.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:5779f264-7c4e-4481-9d2b-19c534014abc
uuid:5779f264-7c4e-4481-9d2b-19c534014abc

Subject:

pramiracetam, hypoxia, epileptic afterdischarges, and hippocampus

Type:

article, model:article, and TEXT

Description:

The possible protective action of pramiracetam, a pyrrolidinone nootropic drug, against hypobaric hypoxia was studied in two age groups of immature rats with implanted electrodes. Epileptic afterdischarges induced by hippocampal stimulation were used as a measure of hypoxic damage. Pramiracetam did not substantially change these afterdischarges in 12- and 18-day-old rat pups which were not exposed to hypoxia. Hypobaric hypoxia (simulated altitude of 7000 m for one hour) led to prolongation of the first afterdischarge in both age groups. Pramiracetam did not influence this prolongation in 12-day-old rats. The first afterdischarge was shortened significantly in 18-day-old animals but not to the level of rats not exposed to hypoxia. The afterdischarges elicited by repeated stimulations (four times at 10 min intervals) did not differ in pramiracetam-treatcd and control rats.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1996 Volume:45 | Number:3

Harvested from:

CDK

Metadata only:

false