Circadian leptin concentration changes in critically ill heart failure patients

Title:

Circadian leptin concentration changes in critically ill heart failure patients

Creator:

Ivan Čundrle, Pavel Suk, Vladimír Šrámek, Zdena Lacinová, and Martin Haluzík

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:598c03c9-9fc8-400a-b462-362e9e1e1089
uuid:598c03c9-9fc8-400a-b462-362e9e1e1089
issn:0862-8408

Subject:

leptin, cirkadiánní rytmy, srdeční selhání, circadian rhythms, heart failure, critical care, 14, and 612

Type:

model:article and TEXT

Format:

print, bez média, and svazek

Description:

Physiologically, leptin concentration is controlled by circadian rhythm. However, in critically ill patients, circadian rhythm is disrupted. Thus we hypothesized that circadian leptin concentration changes are not preserved in critically ill patients. Ten consecutive critically ill heart failure patients with the clinical indication for mechanical ventilation and sedation were included into our study. Plasma leptin concentration was measured every 4 h during the first day (0-24 h) and during the third day (48-72 h) after admission. During the first day, there were significant leptin concentration changes (ANOVA, p<0.05), characterized by an increase in concentration by 44 % (16-58 %); p=0.02 around noon (10 am-2 pm) and then a decrease in concentration by 7 % (1-27 %); p=0.04 in the morning (2 am-6 am). In contrast, there was no significant change in leptin concentration during the third day after admission (ANOVA, p=0.79). Based on our preliminary results, we concluded that in critically ill heart failure patients, the circadian rhythm of plasma leptin concentration seems to be preserved during the first but not during the third day after admission., I. Cundrle Jr., P. Suk, V. Sramek, Z. Lacinova, M. Haluzik., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:3

Harvested from:

CDK

Metadata only:

false