Anticonvulsant effect of SL 75 102 in adult and immature rats

Title:

Anticonvulsant effect of SL 75 102 in adult and immature rats

Creator:

Kubová, H., Haugvicová, R., and Mareš, P.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:5a5a303b-2776-413d-93a9-185750002773
uuid:5a5a303b-2776-413d-93a9-185750002773

Subject:

rat, motor seizures, development, pentylenetetrazol, SL 75 102, and GABA receptor agonist

Type:

article, model:article, and TEXT

Description:

The anticonvulsant action of SL 75 102, a metabolite of Progabide, was studied in a model of pentylenetetrazol- induced motor seizures in adult and 12-day-old rats. SL 75 102 suppressed generalized tonic-clonic seizures in adult rats and restricted the tonic phase of these seizures in rat pups. SL 75 102 was less effective than Progabide. In addition, some minor differences in anticonvulsant actions of these two drugs were observed.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1997 Volume:46 | Number:1

Harvested from:

CDK

Metadata only:

false