Profound alterations in the intrinsic excitability of cerebellar purkinje neurons following neurotoxin 3-acetylpyridine (3-AP)-induced ataxia in rat: new insights into the role of small conductance K+ channels

Title:

Profound alterations in the intrinsic excitability of cerebellar purkinje neurons following neurotoxin 3-acetylpyridine (3-AP)-induced ataxia in rat: new insights into the role of small conductance K+ channels

Creator:

Kaffashian, M., Shabani, M., Goudarzi, I., Behzadi, G., Zali, A., and Janahmadi, M.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:5a5f6415-fdee-4e80-a863-13a1e4a13e39
uuid:5a5f6415-fdee-4e80-a863-13a1e4a13e39

Subject:

Fyziologie člověka a srovnávací fyziologie, neurotoxiny, neurotoxins, cerebellar ataxia, intrinsic excitability, neurotoxin 3-acetylpyridine, purkinje neurons, small conductance Ca2+-activated K+ channels, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Alterations in the intrinsic properties of Purkinje cells (PCs) may contribute to the abnormal motor performance observed in ataxic rats. To investigate whether su ch changes in the intrinsic neuronal excitability could be attributed to the role of Ca2+ -activated K+ channels (KCa ), whole cell current clamp recordings were made from PCs in cerebellar slices of control and ataxic rats. 3-AP induced profound alterations in the intrinsic properties of PCs, as evidenced by a significant increase in both the membrane input resistance and the initial discharge frequency, along with the disruption of the firing regularity. In control PCs, the blockade of small conductance KCa channels by UCL1684 resulted in a significant increase in the membrane input resistance, action potential (AP) half-width, time to peak of the AP and initial discharge frequency. SK channel blockade also significantly decreased the neur onal discharge regularity, the peak amplitude of the AP, the amplitude of the after-hyperpolarization and the spike fr equency adaptation ratio. In contrast, in ataxic rats, both the firing regularity and the initial firing frequency were significantly increased by the blockade of SK channels. In conclusion, ataxia may arise from alterations in the functional contribution of SK channels, to the intrinsic properties of PCs., M. Kaffashian ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:2

Harvested from:

CDK

Metadata only:

false