Sensitivity of the generator of spontaneous motility in chick embryos to the acute and chronic administration of MPTP

Title:

Sensitivity of the generator of spontaneous motility in chick embryos to the acute and chronic administration of MPTP

Creator:

Sedláček, J.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:5c9ecdad-ce7b-4706-b8bb-7502e315d1be
uuid:5c9ecdad-ce7b-4706-b8bb-7502e315d1be

Subject:

chick embryo, spontaneous motility, MPTP, nialamide, and MAO

Type:

article, model:article, and TEXT

Description:

The acute and chronic effect of l-methyl-4-plicnyl-l,2,3,6- tetrahydropyridine (MPTP) on spontaneous motor activity and its development was studied in chick embryos. 1. From the 13th day of incubation, the acute effect of MPTP (30 mg/kg e.w., up to 60 min after administration) consisted in significant depression of spontaneous motility. From the 17th day, the effect of MPTP in supraspinal compartments of the CNS also began to participate in this depression. 2. Flic subacute effect of MPTP (up to 24 h after a single dose) was lethal for 11-day-old embryos. Conversely, in older embryos resting motility partly recovered, with signs of an inverse correlation to the embryo’s age. The final effect, however, consisted in absolute failure of the hatching process. 3. The chronic effect of MPTP (3.57 mg/kg e.w./24 h, from the 4th to the 16th day of incubation) led to a developmental reduction of spontaneous motor activity, chiefly from the 8th to 12th day of incubation. 4. The interaction of nialamide (25 mg/kg e.w.), a blocker of monoaminooxidasc produced disparate results with the effect of MPTP in young and old embryos.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1992 Volume:41 | Number:2

Harvested from:

CDK

Metadata only:

false