Different Sensitivity of Miniature Endplate Currents of the Rat Extensor Digitorum Longus, Soleus and Diaphragm Muscles to a Novel Acetylcholinesterase Inhibitor C-547

Title:

Different Sensitivity of Miniature Endplate Currents of the Rat Extensor Digitorum Longus, Soleus and Diaphragm Muscles to a Novel Acetylcholinesterase Inhibitor C-547

Creator:

Petrov, K.A., Kovyazina, I.V. , Zobov, V.V., Bkharaeva, E.A., Nikolsky, E.E., and Vyskočil , F.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:5fd26f1c-4df0-4151-81c9-4702ee091e8d
uuid:5fd26f1c-4df0-4151-81c9-4702ee091e8d

Subject:

Miniature endplate current, Acetylcholinesterase, and Anticholinesterase

Type:

article, model:article, and TEXT

Description:

A novel derivative of 6-methyluracil, C-547, increased the amplitude and prolonged the duration of miniature endplate currents (MEPCs) which is typical for acetylcholinesterase inhibition. In the soleus and extensor digitorum longus significant potentiation was detected at nanomolar concentrations. In contrast, in the diaphragm muscle, the increase in the amplitudes of the MEPCs and the decay time constant  appeared only when the concentration of C-547 was elevated to 1x10-7 M. Possible consequences for the exploitation of this drug, which can selectively inhibit AChE in particular synapses, are discussed.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2006 Volume:55 | Number:5

Harvested from:

CDK

Metadata only:

false