Testosterone in relation to behavioral problems in pre-pubertal boys with autism spectrum disorders

Title:

Testosterone in relation to behavioral problems in pre-pubertal boys with autism spectrum disorders

Creator:

Pivovarciova, A., Durdiakova, J., Silvia Hnilicová, Filcikova, D., and Daniela Ostatníková

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:5fda274c-5252-4d56-8578-54e05866018f
uuid:5fda274c-5252-4d56-8578-54e05866018f
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, testosteron, hyperaktivita, autismus, testosterone, hyperactivity, autism, autism spectrum disorders, conduct problems, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Autism spectrum disorders (ASD) are neurodevelopmental conditions characterized by impairment in social communication and presence of stereotyped/restricted behaviors. Children with ASD very often demonstrate co-morbid psychiatric problems, problems known to be affected by testosterone in neurotypical populations. However, there are few reports investigating relationships between testosterone and psychiatric conditions in children with ASD. The aim of this study was to determine the relationship between plasmatic levels of testosterone and behavioral/emotional problems in pre-pubertal boys with ASD. The study sample consisted of 31 pre-pubertal boys (ages 3-10) with ASD. Parents completed the Nisonger Child Behavior Rating Form (NCBRF) to assess specific behavioral/emotional problems as observed in the previous 2 months. Plasmatic testosterone levels were determined in boys according to standardized procedures. It was found that there were positive correlations between testosterone levels and the conduct problems subscale (p=0.034, rs=0.382) of NCBRF and also between testosterone levels and the hyperactive subscale (p=0.025, rs=0.402) of NCBRF. Findings in this study are in line with research conducted in the neurotypical population. This is the first large study investigating testosterone and emotional/behavioral problems in ASD and warrants further research in this field in order to clarify the etiopathogenesis of psychiatric co-morbidities and improve their treatment., A. Pivovarciova, J. Durdiakova, S. Hnilicova, D. Filcikova, D. Ostatnikova., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2015 Volume:64 | Number:Suppl 5

Harvested from:

CDK

Metadata only:

false