S100A1: a major player in cardiovascular performance

Title:

S100A1: a major player in cardiovascular performance

Creator:

Cuarte-Costa, S., Castro-Ferreira, R., Neves, J. S., and Leite-Moreira, A. F.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:60b24593-72cc-407a-b30f-6a8b6d18b993
uuid:60b24593-72cc-407a-b30f-6a8b6d18b993
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, srdeční selhání, genová terapie, endoteliální dysfunkce, heart failure, gene therapy, endothelial dysfunction, calcium homeostasis, contractile function, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Calcium cycling is a major determinant of cardiac function. S100A1 is the most abundant member of the calcium-binding S100 protein family in myocardial tissue. S100A1 interacts with a variety of calcium regulatory proteins such as SERCA2a, ryanodine receptors, L-type calcium channels and Na+/Ca2+ exchangers, thus enhancing calcium cycling. Aside from this major function, S100A1 has an important role in energy balance, myofilament sliding, myofilament calcium sensibility, titin-actin interaction, apoptosis and cardiac remodeling. Apart from its properties regarding cardiomyocytes, S100A1 is also important in vessel relaxation and angiogenesis. S100A1 potentiates cardiac function thus increasing the cardiomyocytes’ functional reserve; this is an important feature in heart failure. In fact, S100A1 seems to normalize cardiac function after myocardial infarction. Also, S100A1 is essential in the acute response to adrenergic stimulation. Gene therapy experiments show promising results, although further studies are still needed to reach clinical practice. In this review, we aim to describe the molecular basis and regulatory function of S100A1, exploring its interactions with a myriad of target proteins. We also explore its functional effects on systolic and diastolic function as well as its acute actions. Finally, we discuss S100A1 gene therapy and its progression so far., S. Duarte-Costa, R. Castro-Ferreira, J. S. Neves, A. F. Leite-Moreira., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2014 Volume:63 | Number:6

Harvested from:

CDK

Metadata only:

false