Carnosine and other imidazole-containing compounds enhance the postdenervation depolarization of the rat diaphragm fibres

Title:

Carnosine and other imidazole-containing compounds enhance the postdenervation depolarization of the rat diaphragm fibres

Creator:

Urazaev, A. Kh., Naumenko, N. V., Nikolsky, E. E., and Vyskočil, F.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:63957f3a-d057-45c5-8812-15825e360c37
uuid:63957f3a-d057-45c5-8812-15825e360c37

Subject:

muscle denervation, 7-nitro indazole, imidazole, carnosine, anserine, carbachol, glutamate, and nitric oxide

Type:

article, model:article, and TEXT

Description:

In the presence of carnosine, anserine, histidine, imidazole and 7-nitro indazole, the early postdenervation depolarization of muscle of about 8 mV was significantly increased by 2.15-4.8 mV. The presence of the imidazole ring in the molecule is apparently necessary for this effect. These compounds also eliminated an NO-mediated protective effect of L-glutamate and carbachol on the depolarization of membrane potential. The presence of imidazole, 7-nitro indazole, carnosine and anserine did not significantly change the effect of an external NO donor, sodium nitroprusside. The structural and fuhctional similarity between imidazole derivatives and the known NO synthase inhibitor, 7-nitro indazole suggests that imidazole, carnosine and anserine might act by inhibiting NO production which is stimulated by glutamate and carbachol.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1998 Volume:47 | Number:4

Harvested from:

CDK

Metadata only:

false