Functional coordination of motor activity in colonic smooth muscles in rat experimental model

Title:

Functional coordination of motor activity in colonic smooth muscles in rat experimental model

Creator:

Nedialkova, N., Stavreva, G., Negrev, N., Ivancheva, C., and Radomirov, R.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:63ee235e-d532-4f65-a025-3b8334578740
uuid:63ee235e-d532-4f65-a025-3b8334578740

Subject:

Fyziologie člověka a srovnávací fyziologie, tračník, colon, local networks, motor reflexes, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Spontaneous and electrically-elicited motor activity was recorded by triple organ bath in rat segment-model preparation as display of excitation of local nerve networks and ascending or descending reflex pathways underlying contractile potency and functional coordination of colonic longitudinal and circular muscles. Spontaneous high-amplitude contractions, but not relaxations, appeared synchronously in both muscles. Electrical field stimulation applied to proximal or distal part of segments elicited both tetrodotoxin (0.1 μM)-sensitive local motor responses of the stimulated part and ascending or descending motor responses of the contralateral, nonstimulated part of the preparations. Contract ions characterized the local response of longitudinal muscle. The circular muscle responded with relaxation followed by contraction. Synchronous ascending contractions and descending contraction of the longitudinal muscle and relaxation followed by contraction of the circular muscle were observed when the middle part of segments was stimulated, thus indicating that locally-induced nerve excitation propagated via intrinsic ascending or descending nerve pathways that could be synchronously coactivated by one and the same stimulus. The ascending motor responses were more pronounced and the motor responses of longitudinal muscle were expressed more than those of circular muscle suggesting an essential role of ascending reflex pathways and longitudinal muscle in the coordinated motor activity of colon., N. Nedialkova ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:4

Harvested from:

CDK

Metadata only:

false