Deprenyl and the relationship between its effects on spatial memory, oxidant stress and hippocampal neurons in aged male rats

Title:

Deprenyl and the relationship between its effects on spatial memory, oxidant stress and hippocampal neurons in aged male rats

Creator:

Kiray, M., Bagriyanik, H.A., Pekcetin, C., Ergur, B.U. , Uysal, N., Ozyurt, D., and Buldan, Z.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:63f17038-8b0e-45be-93d9-df7e1538525c
uuid:63f17038-8b0e-45be-93d9-df7e1538525c

Subject:

Deprenyl, Aging, Spatial memory, Lipid peroxidation, Antioxidant enzymes, and Hippocampus

Type:

article, model:article, and TEXT

Description:

Oxidative stress may play a major role in the aging process and associated cognitive decline. Therefore, antioxidant treatment may alleviate age-related impairment in spatial memory. Cognitive impairment could also involve the age-related morphological alterations of the hippocampal formation. The aim of this study was to examine the relationship between the effects of deprenyl, an irreversible monoamine-oxidase B inhibitor, on spatial memory by oxidant stress and on the total number of neurons in the hippocampus CA1 region of aged male rats. In this study, 24-month-old male rats were used. Rats were divided into control and experimental groups which received an injection of deprenyl for 21 days. Learning experiments were performed for six days in the Morris water maze. Spatial learning was significantly better in deprenyl-treated rats compared to saline-treated rats. Deprenyl treatment elicited a significant decrease of lipid peroxidation in the prefrontal cortex, striatum and hippocampus regions and a significant increase of glutathione peroxidase activity in the prefrontal cortex and hippocampus. It was observed that deprenyl had no effect on superoxide dismutase activity. The total number of neurons in the hippocampus CA1 region was significantly higher in the deprenyl group than in the control group. In conclusion, we demonstrated that deprenyl increases spatial memory performance in aged male rats and this increase may be related to suppression of lipid peroxidation and alleviation of the age-related decrease of the number of neurons in the hippocampus. The results of such studies may be useful in pharmacological alleviation of the aging process.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2006 Volume:55 | Number:2

Harvested from:

CDK

Metadata only:

false