Complex sympathetic regulation in adolescent mitral valve prolapse

Title:

Complex sympathetic regulation in adolescent mitral valve prolapse

Creator:

Bona Olexova, Lucia, Visnovcova, Zuzana, Ferencova, Nikola, Jurko, Alexander, and Tonhajzerova, Ingrid

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:64167461-4079-4f03-9eab-e40684fd01ae
uuid:64167461-4079-4f03-9eab-e40684fd01ae
doi:10.33549/physiolres.934830

Subject:

mitral valve prolapse, autonomic nervous system, sympathetic activity, blood pressure, and adolescent age

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Mitral valve prolapse (MVP) belongs to cardiac disorders characterized by impaired closure of mitral leaflets. We studied adolescent group of patients with MVP suffering from symptomatology that cannot be explained by mitral regurgitation alone. Several studies suggested that symptoms can be explained by autonomic, in particular sympathetic-linked dysfunction. Thus, we assessed non-invasive sympathetic indices of blood pressure and heart rate variability and electrodermal activity (EDA). Fifty-three adolescents with MVP (age: 15.1±0.4 years) and 43 healthy age- and gender-matched adolescents (age: 14.9±0.4 years) were examined. Blood pressure, heart rate and EDA were continuously recorded during 6-min rest. Evaluated parameters were: low frequency band of systolic blood pressure variability, systolic, diastolic and mean blood pressure, mean RR interval, cardiac sympathetic indices: symbolic dynamics (0V%), left ventricular ejection time (LVET), pre-ejection period (PEP), and EDA. Our findings revealed significantly higher systolic, diastolic, and mean blood pressure values, shortened mean RR interval, increased 0V%, and shortened LVET in MVP patients vs. controls (p=0.028, p<0.001, p=0.002, p<0.001, p=0.050, p<0.001; respectively). Our study revealed enhanced cardiovascular sympathetic regulation in adolescent MVP patients. We suggest that evaluation of noninvasive sympathetic parameters could represent potential biomarkers for early diagnosis of cardiovascular complications associated with MVP already at adolescent age.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

S317-S325

Source:

Physiological research | 2021 Volume:70 | Number:Supplement 3

Harvested from:

CDK

Metadata only:

false