Renal interactions of renin-angiotensin system, nitrid oxide and superoxide anion: implications in the pathophysiology of salt-sensitivity and hypertension

Title:

Renal interactions of renin-angiotensin system, nitrid oxide and superoxide anion: implications in the pathophysiology of salt-sensitivity and hypertension

Creator:

Libor Kopkan and Luděk Červenka

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:64ebde62-bbda-4096-b4da-3701130a9507
uuid:64ebde62-bbda-4096-b4da-3701130a9507

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, oxid dusnatý, hypertenze, physiology, nitric oxide, hypertension, systém renin-angiotenzin, superoxidový anion, funkce ledvin, citlivost na sůl, renin-angiotensin system, superoxide anion, renal function, salt-sensitivity, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

Renin-angiotensin system (RAS) plays a key role in the regulation of renal function, volume of extracellular fluid and blood pressure. The activation of RAS also induces oxidative stress, particularly superoxide anion (O2-) formation. Although the involvement of O2- production in the pathology of many diseases is known for long, recent studies also strongly suggest its physiological regulatory function of many organs including the kidney. However, a marked accumulation of O2- in the kidney alters normal regulation of renal function and thus may contribute to the development of salt-sensitivity and hypertension. In the kidney, O2- acts as vasoconstrictor and enhances tubular sodium reabsoption. Nitric oxide (NO), another important radical that exhibits opposite effects than O2-, is also involved in the regulation of kidney function. O2- rapidly interacts with NO and thus, when O2- production increases, it diminishes the bioavailability of NO leading to the impairment of organ function. As the activation of RAS, particularly the enhanced production of angiotensin II, can induce both O2- and NO generation, it has been suggested that physiological interactions of RAS, NO and O2- provide a coordinated regulation of kidney function. The imbalance of these interactions is critically linked to the pathophysiology of salt-sensitivity and hypertension., L. Kopkan, L. Červenka., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2009 Volume:58 | Number:Suppl 2

Harvested from:

CDK

Metadata only:

false