Brain lipid binding protein (FABP7) as modulator of astrocyte function

Title:

Brain lipid binding protein (FABP7) as modulator of astrocyte function

Creator:

Kipp, M., Clarner, T., Gingele, S., Pott, F., Amor, S., Valk, P. van der, and Beyer, C.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:6590d658-eff8-495a-bbf0-64ed2203e753
uuid:6590d658-eff8-495a-bbf0-64ed2203e753

Subject:

Fyziologie člověka a srovnávací fyziologie, roztroušená skleróza, regenerace (biologie), multiple sclerosis, regeneration (biology), oligodendrocyte, astroglia, remyelination, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Over a century ago, hyperplasia and hypertrophy of astrocytes was noted as a histopathological hallmark of multiple sclerosis and was hypothesized to play an important role in the development and course of this disease. However until today, the factual contribution of astrocytes to multiple sclerosis is elusive. Astrocytes may play an active role during degeneration and demyelination by controlling local inflammation in the CNS, provoking damage of oligodendrocytes and axons, and glial scarring but might also be beneficial by creating a permissive environment for remyelination and oligodendrocyte precursor migration, proliferation, and differentiation. Recent findings from our lab suggest that brain lipid binding protein (FABP7) is implicated in the course of multiple sclerosis and the regulation of astrocyte function. The relevance of our findings and data from other groups are highlighted and discussed in this paper in the context of myelin repair., M. Kipp ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false