Changes of muscle-derived cytokines in relation to thiol redox status and reactive oxygen and nitrogen species

Title:

Changes of muscle-derived cytokines in relation to thiol redox status and reactive oxygen and nitrogen species

Creator:

Zembron-Lacny, A., Naczk, M., Gajewski, M., Ostapiuk-Karolczuk, J., Dziewiecka, H., Kasperska, A., and Szyszka, K.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:6680c327-147b-4237-b579-0b1766491ce6
uuid:6680c327-147b-4237-b579-0b1766491ce6
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, oxid dusnatý, nitric oxide, muscle damage, hydrogen peroxide, thiol redox, interleukins, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The aim of this study was to co mpare the levels of the plasma muscle-derived cytokines (myokines) and reactive oxygen and nitrogen species (RONS) after muscle damage triggered by different exercises, and to demonstrate the relationships between RONS, thiol redox status and myokines. Sixteen young men participated in a 90-min run at 65 % VO 2 max (Ex.1) or 90-min run at 65 % VO 2 max finished with a 15-min eccentric phase (Ex.2, downhill running). Plasma samples were collected before and at 20 min, 24 h and 48 h after exercise. The exercise trials significantly elevated the concen trations of plasma hydrogen peroxide (H2O2) and 8-isoprostane at 20 min rest. Myokines IL-6 and IL-10 increased at 20 min rest while IL-1 β and TNF α increased at 24 h rest following both running. Ex.2 caused a significant increase in nitric oxide (NO), IL-6, IL-10 and oxidized glutathione (GSSG) levels. Thiol redox status (GSHtotal-2GSSG/GSSG) decreased by about 30 % after Ex.2 as compared to Ex.1. H 2 O 2 and NO directly correlated with IL-6, IL-10, IL-1 β , TNF α and glutathione. These results show that eccentric work is an important factor that enhances the production of RONS and muscle-derived cytokines, and that there is a possible participation of thiol redox status in the release of myokines to blood., A. Zembron-Lacny, M. Naczk, M. Gajewski, J. Ostapiuk-Karolczuk, H. Dziewiecka, A. Kasperska, K. Szyszka., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2010 Volume:59 | Number:6

Harvested from:

CDK

Metadata only:

false