Metabolic and renal effects of dietary advanced glycation end products in pregnant rats

Title:

Metabolic and renal effects of dietary advanced glycation end products in pregnant rats

Creator:

Janšáková, K. , Lengyelová, E. , Pribulová, N., Somoza, V. , Celec, P. , Šebeková, K. , Ostatníková, D. , and Tóthová, Ľ.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:66991b84-2882-44ca-a164-746a2f9fb060
uuid:66991b84-2882-44ca-a164-746a2f9fb060
doi:10.33549/physiolres.934102

Subject:

glycotoxins, melanoidins, maillard reaction products, metabolic syndrome, and insulin sensitivity

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

Thermally processed food contains advanced glycation end products (AGEs) including Nε -(carboxymethyl)lysine (CML). Higher AGEs or circulating CML were shown to be associated with pregnancy complications such as preeclampsia and gestational diabetes. It is unclear whether this association is causal. The aim of our study was to analyze the effects of dietary CML and CML-containing thermally processed food on metabolism in pregnant rats. Animals were fed with standard or with AGE-rich diet from gestation day 1. Third group received standard diet and CML via gavage. On gestation day 18, blood pressure was measured, urine and blood were collected and the oral glucose tolerance test was performed. Plasma AGEs were slightly higher in pregnant rats fed with the AGE-rich diet (p=0.09). A non-significant trend towards higher CML in plasma was found in the CML group (p=0.06). No significant differences between groups were revealed in glucose metabolism or markers of renal functions like proteinuria and creatinine clearance. In conclusion, this study does not support the hypothesis that dietary AGEs such as CML might induce harmful metabolic changes or contribute to the pathogenesis of pregnancy complications. The short duration of the rodent gestation warrants further studies analyzing long-term effects of AGEs/CML in preconception nutrition.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

467-479

Source:

Physiological research | 2019 Volume:68 | Number:3

Harvested from:

CDK

Metadata only:

false