Age, genetic characteristics and number of cycles are critical factors to consider for successful protection of the murine heart with postconditioning

Title:

Age, genetic characteristics and number of cycles are critical factors to consider for successful protection of the murine heart with postconditioning

Creator:

Somers, S. J., Lacerda, L., Opie, L., and Lecour, S.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:6a38be88-d246-47ed-a5bb-53402d04f0bc
uuid:6a38be88-d246-47ed-a5bb-53402d04f0bc

Subject:

Fyziologie člověka a srovnávací fyziologie, ischemie, ischemia, reperfusion, postconditioning, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Postconditioning (PostC) is a re cently discovered phenomenon whereby brief repetitive cycles of ischaemia with intermittent reperfusion following prolonged is chaemia elicit cardioprotection. This study investigated whether the age, genetic characteristics or number of repetitive cycles influenced the protective effect of PostC in mice. C57BL/6 floxed or non-floxed STAT-3 mice aged between 14-16 weeks (young) or 18-20 weeks (older) were perfused on a Langendorff apparatus and subjected to 35 min global ischaemia and 45 min reperfusion. PostC was elicited by either 3 (PostC-3) or 6 cycles (PostC-6) of 10s ischaemia and 10 s reperfusion. PostC-3 and PostC-6 in both young and older non-floxed mice reduced the myocar dial infarct size. In contrast, only PostC-3 reduced myocardial infarct size in young floxed mice. Neither PostC-3 nor PostC-6 reduced the in farct in older floxed mice. Our data reveal that genetic characteristics, a minute difference in age or the nu mber of postconditioning cycles are critical factors to be consid ered for the successful effect of ischaemic postconditioning in a murine model. Moreover, these factors should be taken into consideration for future experimental research or clinical applications of this protective phenomenon., S. J. Somers ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:6

Harvested from:

CDK

Metadata only:

false