Role of L-DOPA in spinal nociceptive reflex activity: higher sensitivity of Aδ versus C fibre-evoked nociceptive reflexes to L-DOPA

Title:

Role of L-DOPA in spinal nociceptive reflex activity: higher sensitivity of Aδ versus C fibre-evoked nociceptive reflexes to L-DOPA

Creator:

Schomburg, E. D., Bibaj, P., and Steffens, H.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:6c093422-b1b9-45b4-aea6-1c27453ba199
uuid:6c093422-b1b9-45b4-aea6-1c27453ba199

Subject:

Fyziologie člověka a srovnávací fyziologie, bolest, mícha, pain, spinal cord, L-DOPA, TTX, Aδ-fibres, nociceptive reflexes, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

The role of L-DOPA in spinal nociceptive reflex activity has been re-evaluated. In high spinal ca ts, with supraspinal loops being excluded, the onset of reflex facilitation induced by noxious radiant heat is delayed after injection of L-DOPA by 4 to 10 s, i.e. the early component of nociceptive reflex facilitation is blocked, while the late component persisted. Further investigations have shown that the early component of reflex facilitation induced by noxious radiant heat is mediated by Aδ-fibres and the late component by C-fibres. Therefore, it can be assumed that L-DOPA, like opioids, preferentially blocks the transmission in nociceptive reflex pathways from Aδ-fibres., E. D. Schomburg, P. Dibaj, H. Steffens., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:4

Harvested from:

CDK

Metadata only:

false