Differential impact of acute bout of exercise on redox- and oxidative damage-related profiles between untrained subjects and amateur runners

Title:

Differential impact of acute bout of exercise on redox- and oxidative damage-related profiles between untrained subjects and amateur runners

Creator:

Falone, S., Mirabilio, A., Pennelli, A., Cacchio, CM., Di Baldassarre, A., Gallina, S., Passerini, A., and Amicarelli, F.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:6c2491a7-59af-404f-84f6-39d8068cfa9f
uuid:6c2491a7-59af-404f-84f6-39d8068cfa9f
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, oxidační stres, tělesná kondice, oxidative stress, physical fitness, aerobic exercise, reactive oxygen species, lipid peroxidation, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Despite the demonstrated exercise -induced increase in reactive oxygen species (ROS) production, growing epidemiological evidence indicates that habitual, moderate physical activity reduces the incidence of several oxidative stress-based diseases. This apparent paradox can be explained taking into account that ROS produced during repeated ex ercise bouts may act as mild stressors able to trigger physiological and biomolecular hormetic responses through a number of redox-sensitive transcription pathways. Unfortunately, much more limited information is available from general population-based research, which could better reflect the condition of common people interested in achieving and maintaining good fitness levels. The present work aimed at investigatin g whether and how exercise-related habits in non-professional regular runners (n=33) can affect the systemic anti-oxidative capacity, and the resting serum levels of typical lipid peroxidation-related by-products and oxidatively- damaged proteins, in comparison with untrained sedentary individuals (n=25). We also anal yzed in both groups the redox response elicited by a modified Bruce-based maximal exercise test on the same parameters. Our findings indicated that long- term regular and moderate practice of aerobic physical activity can increase antioxidant defense systems, lower the resting protein oxidation processes and reduce the immediate up- regulation of lipid-targeting oxidative stress in response to an acute bout of exercise., S. Falone, A. Mirabilio, A. Pennelli, M. Cacchio, A. Di Baldassarre, S. Gallina, A. Passerini, F. Amicarelli., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2010 Volume:59 | Number:6

Harvested from:

CDK

Metadata only:

false