The role of renin-angiotensin system in prothrombotic state in essential hypertension

Title:

The role of renin-angiotensin system in prothrombotic state in essential hypertension

Creator:

Anna Remková and Milan Remko

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:6c258545-3b3c-47f8-86b7-d13337b7adb0
uuid:6c258545-3b3c-47f8-86b7-d13337b7adb0

Subject:

Fyziologie člověka a srovnávací fyziologie, endotel, hypertenze, endothelium, hypertension, platelet, coagulation, fibrionolysis, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Rheological, haemostatic, endothelial and platelet abnormalities appear to play a role in the thrombotic complications of hypertension. This prothrombotic/hypercoagulable state in hypertension may contribute to the increased risk and severity of target organ damage. It can be induced by the activated reninangiotensin system (RAS), with abnormalities in endothelial and platelet function, coagulation and fibrinolysis. Treatment of uncomplicated essential hypertension by RAS targeting antihypertensive therapy could result in a reversal of prothrombotic abnormalities, contributing to a reduction of thrombosis-related complications. Since angiotensin converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) have two distinct mechanisms of RAS interruption, it is hypothesized that each therapy might have different impact on the prothrombotic state in hypertensive patients. Some studies demonstrate a beneficial effect of both ACE inhibitors and ARBs on prothrombotic state, in addition to their efficacy to normalize elevated blood pressure. The potentially antithrombotic effect of the RAS inhibiting agents may in turn support the preservation of cardiovascular function. Available data may offer an additional explanation for the efficacy of the RAS targeting agents in the prevention of cardiovascular events in patients with atherosclerotic vascular disease., A. Remková, M. Remko., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2010 Volume:59 | Number:1

Harvested from:

CDK

Metadata only:

false