Alkaline phosphatase activity of duodenal enterocytes after neonatal administration of monosodium glutamate to rats

Title:

Alkaline phosphatase activity of duodenal enterocytes after neonatal administration of monosodium glutamate to rats

Creator:

Mozeš, Š., Ľudovít Lenhardt, and Martinková, A.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:6de1087f-b0d8-4c71-a6a0-9b4d486c92c8
uuid:6de1087f-b0d8-4c71-a6a0-9b4d486c92c8
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, obezita, obesity, alkaline phosphatase activity, duodenal enterocytes, monosodium glutamate, rat, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

In the present work neonatal male and female Wistar rats were treated intraperitoneally with monosodium glutamate (MSG 2 mg/kg b.w.) or saline (controls) daily for 4 day after birth. At the age of 30 and 80 days, the alkaline phosphatase activity (AP) in the brush border of individual enterocytes, the body fat content and Lee´s index of obesity were analyzed. Microdensitometrical quantification of AP was significantly increased on day 30 in males (P<0.01) and on day 80 in MSG-treated male and female rats (P<0.001) as compared to the controls. MSG administration also increased the body fat weight and the obesity index significantly (P<0.001) in 80-day-old animals, but was without any significant effect on their food intake. Our results showed that a) neonatal MSG-treatment may significantly change the intestinal function and b) the investigation of the intestinal enzyme activities may be important in further studies on MSG-induced and other forms of obesity., Š. Mozeš, Ľ. Lenhardt, A. Martinková., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2000 Volume:49 | Number:2

Harvested from:

CDK

Metadata only:

false