The changes in pineal N-acetyltransferase activity, pineal and serum melatonin concentration in rats after irradiation of the head

Title:

The changes in pineal N-acetyltransferase activity, pineal and serum melatonin concentration in rats after irradiation of the head

Creator:

Kassayová, M., Ahlersová, E., Ahlers, I., and Milárová, R.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:6f856a5b-eed4-4efb-9d8f-ffd299c205a3
uuid:6f856a5b-eed4-4efb-9d8f-ffd299c205a3

Subject:

head gamma irradiation, rats, pineal N-acetyltransferase activity, and pineal melatonin content

Type:

article, model:article, and TEXT

Description:

Male Wistar rats adapted to a light/dark cycle (LD) 12:12 h were exposed in the darkness to a single dose of 14.35 Gy gamma rays on the head with the body shielded. Irradiated and sham-irradiated rats were kept again in the 12 h LD cycle with a free access to food and water till the analysis performed in the darkness. Pineal N-acetyltransferase activity and melatonin content, the serum concentration of the melatonin, corticosterone, thyrotropin and thyroid hormones were determined. N-acetyltransferase activity was lower 2-24 h after irradiation non-significantly whereas between 3-10 days it did not differ from the controls. Radiation decreased the pineal melatonin content and its serum concentration 2 h after exposure and increased them significantly 1-3 days after irradiation. No changes in melatonin levels were found on postirradiation days 5-10. The corticosterone concentration was increased 2 h after exposure only. Local head irradiation changed neither thyrotropin nor thyroid hormone levels.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1993 Volume:42 | Number:6

Harvested from:

CDK

Metadata only:

false