Circadian molecular clocks tick along ontogenesis

Title:

Circadian molecular clocks tick along ontogenesis

Creator:

Alena Sumová, Zdeňka Bendová, Martin Sládek, El-Hennamy, R., Matějů, K., Lenka Polidarová, Serhiy Sosniyenko, and Helena Illnerová

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:71a970cd-715d-4ae9-b88c-d568a115b559
uuid:71a970cd-715d-4ae9-b88c-d568a115b559
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, neurofyziologie, cirkadiánní rytmy, ontogeneze, neurophysiology, circadian rhythms, ontogeny, suprachiasmatic nucleus, peripheral clock, clock gene, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The circadian system controls the timing of behavioral and physiological functions in most organisms studied. The review addresses the question of when and how the molecular clockwork underlying circadian oscillations within the central circadian clock in the suprachiasmatic nuclei of the hypothalamus (SCN) and the peripheral circadian clocks develops during ontogenesis. The current model of the molecular clockwork is summarized. The central SCN clock is viewed as a complex structure composed of a web of mutually synchronized individual oscillators. The importance of development of both the intracellular molecular clockwork as well as intercellular coupling for development of the formal properties of the circadian SCN clock is also highlighted. Recently, data has accumulated to demonstrate that synchronized molecular oscillations in the central and peripheral clocks develop gradually during ontogenesis and development extends into postnatal period. Synchronized molecular oscillations develop earlier in the SCN than in the peripheral clocks. A hypothesis is suggested that the immature clocks might be first driven by external entraining cues, and therefore, serve as “slave” oscillators. During ontogenesis, the clocks may gradually develop a complete set of molecular interlocked oscillations, i.e., the molecular clockwork, and become self-sustained clocks., A. Sumová, Z. Bendová, M. Sládek, R. El-Hennamy, K. Matějů, L. Polidarová, S. Sosniyenko, H. Illnerová., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:Suppl 3

Harvested from:

CDK

Metadata only:

false