Cough, Expiration and Aspiration Reflexes following Kainic Acid Lesions to the Pontine Respiratory Group in Anesthetized Cats

Title:

Cough, Expiration and Aspiration Reflexes following Kainic Acid Lesions to the Pontine Respiratory Group in Anesthetized Cats

Creator:

Poliaček, I., Jakuš, J., Stránsky, A., Baráni, H., Halašová, E., and Tomori, Z.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:75bc7ff2-408a-4568-b6cd-5b3a9701514b
uuid:75bc7ff2-408a-4568-b6cd-5b3a9701514b

Subject:

Pontine respiratory group, Cough, Defensive airway reflexes, Kainic acid lesion, and Cat

Type:

article, model:article, and TEXT

Description:

The importance of neurons in the pontine respiratory group for the generation of cough, expiration, and aspiration reflexes was studied on non-decerebrate spontaneously breathing cats under pentobarbitone anesthesia. The dysfunction of neurons in the pontine respiratory group produced by bilateral microinjection of kainic acid (neurotoxin) regularly abolished the cough reflexes evoked by mechanical stimulation of both the tracheobronchial and the laryngopharyngeal mucous membranes and the expiration reflex mechanically induced from the glottis. The aspiration reflex elicited by similar stimulation of the nasopharyngeal region persisted in 73 % of tests, however, with a reduced intensity compared to the pre-lesion conditions. The pontine respiratory group seems to be an important source of the facilitatory inputs to the brainstem circuitries that mediate cough, expiration, and aspiration reflexes. Our results indicate the significant role of pons in the multilevel organization of brainstem networks in central integration of the aforementioned reflexes.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2004 Volume:53 | Number:2

Harvested from:

CDK

Metadata only:

false