Absence of a significant interaction of two common NOS1 and 5-HTT polymorphisms on sensorimotor gating in humans

Title:

Absence of a significant interaction of two common NOS1 and 5-HTT polymorphisms on sensorimotor gating in humans

Creator:

Rovný, Rastislav, Marko, Martin, Minárik, Gabriel, and Riečanský, Igor

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:7625b909-b4d7-4403-82b7-6bd44965a4d6
uuid:7625b909-b4d7-4403-82b7-6bd44965a4d6
doi:10.33549/physiolres.934819

Subject:

prepulse inhibition, serotonin, serotonin transporter, nitric oxide, and endophenotype

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

The neurotransmitter serotonin has been critically implicated in the pathogenesis of several mental disorders. The serotonin transporter (5-HTT) is a key regulator of serotonergic neurotransmission and its genetic variability is associated with increased risk of psychopathology. One well known polymorphic locus in the 5-HTT gene affecting its expression is a tandem repeat in the promoter region (5-HTTLPR). It has been reported that 5-HTT is functionally coupled with the neuronal nitric oxide synthase (NOS1 or nNOS), an enzyme catalyzing the production of nitric oxide (NO). We have previously demonstrated that a tandem repeat polymorphism in the promoter of NOS1 exon 1f (Ex1f-VNTR) is associated with sensorimotor gating, a marker of inhibitory processing and a well-established endophenotype of several neuropsychiatric disorders. Here we investigated the combined genetic effects of NOS1 Ex1f-VNTR and 5-HTTLPR on sensorimotor gating, measured by prepulse inhibition (PPI) of the acoustic startle reflex, in 164 healthy adults. We found no evidence for the interaction between NOS1 Ex1f-VNTR and 5-HTTLPR on PPI. PPI was associated with NOS1 Ex1f-VNTR, but not 5-HTTLPR. Our data suggest that while NOS1 plays a role in sensorimotor gating, the nitrergic pathway of gating regulation does not involve the action of 5-HTT.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

S387-S395

Source:

Physiological research | 2021 Volume:70 | Number:Supplement 3

Harvested from:

CDK

Metadata only:

false