The determination of optimal initial tension in rat coronary artery using wire myography

Title:

The determination of optimal initial tension in rat coronary artery using wire myography

Creator:

Ping, N.-N., Cao, L., Xiao, X., and Cao, Y.-X.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:77414d4e-ae37-4259-b72e-95ee53855cd0
uuid:77414d4e-ae37-4259-b72e-95ee53855cd0

Subject:

Fyziologie člověka a srovnávací fyziologie, věnčité tepny, coronary arteries, coronary artery, normalization procedure, optimal initial tension, wire myograph, rat, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

The aim of the present study was to determine the optimal initial tension, i.e. initial stretch for rat coronary artery when using the multi-wire myograph system. We used the normalization procedure to mimic physiological conditions and to stretch the coronary arterial segments to normalized internal circumference (IC 1 ). It is determined the internal circumference when the vessel relaxed under a transmural pressure of 100 mm Hg (IC 100 ), and the IC 1 is calculated by multiplying the IC 100 by a factor k. The impact of different factor k on the initial stretch and agonist- induced tension of coronary arteries were investigated. The results showed that the maximal agonist-induced tension was achieved at the factor k value of 0.90 and the initial stretch tension was given 1.16±0.04 mN/mm. The most appropriate factor k value was 0.90-0.95 and the most appropriate initial tension was 1.16-1.52 mN/mm. Th e equilibration time of the coronary artery segments should be at least 1.0 h. In the same optimal initial tension, the agonist-induced tension increased as equilibration time lengthened., N.-N. Ping ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2014 Volume:63 | Number:1

Harvested from:

CDK

Metadata only:

false