Plasma tissue factor in coronary artery disease: further step to the understanding of the basic mechanisms of coronary artery thrombosis

Title:

Plasma tissue factor in coronary artery disease: further step to the understanding of the basic mechanisms of coronary artery thrombosis

Creator:

Jan Vojáček, Jan Dušek, Josef Bis, Josef Šťásek, and Martin Blažek

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:77512943-e7c4-4891-853a-877e4ff6f958
uuid:77512943-e7c4-4891-853a-877e4ff6f958
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, věnčité tepny, arteriální trombóza, physiology, coronary arteries, arterial thrombosis, tkáňový faktor, tissue factor, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Tissue factor is a cell surface protein that is expressed constitutively by monocytes, macrophages and fibroblasts, but also by some other cells in response to a variety of stimuli. The main function of the tissue factor is to form a complex with factor VII/VIIa that converts factors IX and X to their active forms. Tissue factor is also involved in the pathophysiology of systemic inflammatory disorders, coagulopathies, atherosclerotic disease, tumor angiogenesis and metastasis. Increased tissue factor expression either locally in the coronary plaques or systematically on circulating blood elements of patients with acute coronary syndromes may be responsible for increased thrombin generation, thus leading to platelet activation and fibrin formation. Tissue factor therefore plays a pivotal role in the initiation of thrombotic complications in patients with coronary artery disease., J. Vojáček, J. Dušek, J. Bis, J. Šťásek, M. Blažek., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:1

Harvested from:

CDK

Metadata only:

false