Regulation of catecholamine-synthesising enzymes and β-adrenoceptors gene expression in ventricles of stressed rats

Title:

Regulation of catecholamine-synthesising enzymes and β-adrenoceptors gene expression in ventricles of stressed rats

Creator:

Spasojevic, N., Gavrilovic, L., and Dronjak, S.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:793183e0-5309-4ae7-89bf-189280c705fd
uuid:793183e0-5309-4ae7-89bf-189280c705fd

Subject:

Fyziologie člověka a srovnávací fyziologie, genová exprese, stres (fyziologie), gene expression, stress (physiology), chronic stress, ventricles, catecholamine enzymes, β-adrenoceptors, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Stress exposure activates the sympathoneural system, resulting in catecholamine release. Chronic stress is associated with development of numerous disorders, including cardiovascular diseases. Here we investigated the expression of mRNAs for catecholamine biosynthetic enzymes tyrosine-hydroxylase, dopamine-ß-hydroxylase and phenylethanolamine N-methyl- transferase, and for ß1- and ß2-adrenoceptors in the right and left ventricles of rats exposed to chronic unpredictable mild stress. The tyrosine-hydroxylase and dopamine-ß-hydroxylase mRNA levels were not affected by stress, whereas the phenylethanolamine N-methyltransferase mRNA levels significantly increased in both right and left ventricles. No changes in ß1-adrenoceptor mRNA levels in either right or left ventricles were observed. At the same time, stress produced a significant increase of β2-adrenoceptor mRNA levels in left ventricles. These results suggest that elevated expression of phenylethanolamine N-methyltransferase in both ventricules and ß2-adrenoceptor genes in left ventricles could provide a molecular mechanism that leads to altered physiological response, which is important for the organism coping with stress., N. Spasojevic, L. Gavrilovic, S. Dronjak., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false