Exercise training enhansec flow-mediated dilation in spontaneously hypertensive rats

Title:

Exercise training enhansec flow-mediated dilation in spontaneously hypertensive rats

Creator:

Gündüz, F., Koçer, G., Ülker, S., Meiselman, H. J., Başkurt, O. K., and Şentürk, Ü. K.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:79fbbbe7-4650-4e58-a611-074b987b47e4
uuid:79fbbbe7-4650-4e58-a611-074b987b47e4

Subject:

Fyziologie člověka a srovnávací fyziologie, oxid dusnatý, prostaglandiny, nitric oxide, prostaglandins, EDHF, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

This study investigated the effect of exercise training on the flow- mediated dilation (FMD) in gastrocnemius muscle arteries from spontaneously hypertensive rats (SHR). SHR and WKY rats were divided into sedentary and exercised groups. After swimming exercise for eight weeks, the isolated arteries were mounted on pressurized myograph and FMD re sponses examined. The role of nitric oxide (NO), prostaglandins (PGs) and endothelium derived hyperpolarizing factor (EDHF) on FMD were assessed by obtaining dilation responses in the presence and absence of pharmacological antagonists. Nω-nitro-L-arginine methyl ester (L-NAME), indomethacin (INDO) and tetraethylamonium (TEA) were used to inhibit nitric oxide synthase, cyclooxygenase and EDHF-mediated responses, respectively. The FMD response was significantly blunted in arteries of SHR compared with WKY rats, and, improved by exercise training in SHR (SHR-ET) group. In SHR arteries, L-NAME and TEA did not affect dilation responses to flow, while INDO led to a significant enhancement in this response. Although dilation response was not altered by L-NAME in arteries obtained from trained SHR, TEA caused a significant attenuation and INDO led to significant increases. These results demonstrate that exercise training improves FMD in SHR, and, this enhancement induced by exercise training occurs through EDHF-mediated mechanism(s)., F. Gündüz ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:4

Harvested from:

CDK

Metadata only:

false