Mechanisms of the 14-3-3 protein function: regulation of protein function through conformational modulation

Title:

Mechanisms of the 14-3-3 protein function: regulation of protein function through conformational modulation

Creator:

Obsilova, V., Marie Kopecká, Kosek, D., Kacirova, M., Kylarova, S., Rezabkova, L., and Obsil, T.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:7a0a5522-f03f-4144-8f05-39e220816abe
uuid:7a0a5522-f03f-4144-8f05-39e220816abe

Subject:

Fyziologie člověka a srovnávací fyziologie, bílkoviny, proteins, 14-3-3 protein, regulator of G-protein signalling (RGS3), phosducin, neutral trehalase, Bmh1, conformation, signaling, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Many aspects of protein function regulation require specific protein-protein interactions to carry out the exact biochemical and cellular functions. The highly conserved members of the 14-3-3 protein family mediate such interactions and through binding to hundreds of other proteins provide multitude of regulatory functions, thus playing key roles in many cellular processes. The 14-3-3 protein binding can affect the function of the target protein in many ways including the modulation of its enzyme activity, its subcellular localization, its structure and stability, or its molecular interactions. In this minireview, we focus on mechanisms of the 14-3- 3 protein-dependent regulation of three important 14-3-3 binding partners: yeast neutral trehalase Nth1, regulator of G-protein signaling 3 (RGS3), and phosducin., V. Obsilova ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2014 Volume:63 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false