Phthalate metabolites in maternal and cord plasma and their relations to other selected endocrine disruptors and steroids

Title:

Phthalate metabolites in maternal and cord plasma and their relations to other selected endocrine disruptors and steroids

Creator:

Lucie Kolátorová Sosvorová, Jana Vítků, Vavrous, A, Richard Hampl, Karolína Adamcová, Marie Šimková, Antonín Pařízek, Luboslav Stárka, and Michaela Dušková

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:7b86f11e-7036-4ae0-8288-cacebe4205e9
uuid:7b86f11e-7036-4ae0-8288-cacebe4205e9
issn:0862-8408

Subject:

těhotenství, ftaláty, bisfenol A, steroidy, pregnancy, phthalates, bisphenol A, steroids, endocrine disruptor, 14, and 612

Type:

model:article and TEXT

Format:

print, bez média, and svazek

Description:

Endocrine disruptors (EDs) are known to have harmful effects on the human endocrine system; special effort is actually given to the exposure during pregnancy. Humans are usually exposed to a mixture of EDs, which may potentiate or antagonize each other, and the combined effect may be difficult to estimate. The main phthalate monoesters monoethyl-, mono-n -butyl-, monoisobutyl-, monobenzyl-, mono-(2-ethylhexyl)-, mono-(2- ethyl-5-hydroxyhexyl)- and mono-(2-ethyl-5-oxohexyl) phthalate were determined in 18 maternal (37th week of pregnancy) and cord plasma samples using liquid chromatography-tandem mass spectrometry. Previously determined levels of selected bisphenols, parabens and steroids were also considered in this study. In cord blood, there were significantly higher mono-n-butyl phthalate levels than in maternal blood (p=0.043). The results of multiple regression models showed that maternal plasma phthalates were negatively associated with cord plasma androstenedione, testosterone and dehydroepiandrosterone and positively associated with estradiol and estriol. For estriol, a cumulative association was also observed for Σbisphenols. To the best of our knowledge, this is the first pilot study evaluating the effect of prenatal exposure by multiple EDs on newborn steroidogenesis. Our results confirmed phthalate accumulation in the fetal area and disruption of fetal steroidogenesis. This preliminary study highlights the negative impacts of in utero EDs exposure on fetal steroidogenesis., L. Kolatorova, J. Vitku, A. Vavrous, R. Hampl, K. Adamcova, M. Simkova, A. Parizek, L. Starka, M. Duskova., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:Suppl 3

Harvested from:

CDK

Metadata only:

false