Prague hereditary hypercholesterolemic (PHHC) rat - a model of polygenic hypercholesterolemia

Title:

Prague hereditary hypercholesterolemic (PHHC) rat - a model of polygenic hypercholesterolemia

Creator:

Jan Kovář, Zbyněk Tonar, Marie Heczková, and Rudolf Poledne

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:7c951cda-980b-4cd8-bd45-01112e734005
uuid:7c951cda-980b-4cd8-bd45-01112e734005

Subject:

Patologie. Klinická medicína, klinické lékařství, potkan, hypercholesterolémie, genetika, metabolismus cholesterolu, clinical medicine, Rattus norvegicus, hypercholesterolemia, genetics, cholesterol metabolism, 14, and 616

Type:

article, články, model:article, and TEXT

Description:

Prague hereditary hypercholesterolemic (PHHC) rat – rat strain crossbred from Wistar rats – is a model of hypercholesterolemia induced by dietary cholesterol. Importantly, no bile salts and/or antithyroid drugs need to be added to the diet together with cholesterol to induce hypercholesterolemia. PHHC rats have only modestly increased cholesterolemia when fed a standard chow and develop hypercholesterolem ia exceeding 5 mmol/l on 2 % cholesterol diet. Most of the cholesterol in hypercholesterolemic PHHC rats is found in VLDL that become enriched with cholesterol (VLDL-C/VLDL-TG ratio > 1.0). Concurrently, both IDL and LDL concentrations rise without any increase in HDL. PHHC rats do not markedly differ from Wistar rats in the activities of enzymes involved in intravascular remodelation of lipoproteins (lipoprotein and hepatic lipases and lecithin:cholesterol acyltransferase), LDL catabolism, cholesterol turnover rate and absorption of dietary cholesterol. The feeding rats with cholesterol diet results in development of fatty liver in spite of suppression of cholesterol synthesis. However, even though cholesterolemia in PHHC rats is comparable to human hypercholesterolemia, the PHHC rats do not develop atherosclerosis even after 6 months on 2 % cholesterol diet. Importantly, the crossbreeding experiments documented that hypercholesterolemia of PHHC rats is polygenic. To identify the genes that may be involved in pathogenesis of hypercholesterolemia in this strain, the studies of microarray gene expression in the liver of PHHC rats are currently in progress., J. Kovář ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2009 Volume:58 | Number:Suppl 2

Harvested from:

CDK

Metadata only:

false