The role of ACTH in the pathogenesis of polycistic ovarian syndrome in rats: hormonal profiles and ovarian morphology

Title:

The role of ACTH in the pathogenesis of polycistic ovarian syndrome in rats: hormonal profiles and ovarian morphology

Creator:

Baravalle, C., Salvetti, N. R., Mira, G. A., Lorente, J. A., and Ortega, Hugo H.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:7fb38a23-426b-4bda-90a1-099d9472fce9
uuid:7fb38a23-426b-4bda-90a1-099d9472fce9
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, vaječníky, syndrom polycystických ovarií, stres (fyziologie), krysa obecná, physiology, ovaries, polycystic ovary syndrome, stress (physiology), Rattus rattus, ACTH, ACTH (adrenocorticotrophic hormone), 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Numerous hypotheses have been proposed about the pathogenesis of the polycystic ovarian syndrome (PCOS). However, hormonal control of persistent follicles has not be enestablished. The objective of the present study was to compare the follicular structure and hormonal profiles of rats treated with the adrenocor ticotrophic hormone (ACTH) with two experimental models of PCOS. ACTH-treated animals were compared with those exposed to continuous light, those treated with estradiol valerate, and with control (in proestrous and diestrous). Serum hormone levels, histomorphometrical changes, and immunoexpression of vimentin, cytokeratins, cadherins, and proliferating cell nuclear antigen (PCNA) were examined. Treatment with ACTH resulted in an elevation of corticosterone secretion with LH reduction but without changes in ovarian morphology. Although stress (or ACTH) stimulation may be only one of pathophysiological mechanisms involved in follicular cystathogenesis in other species, we do not have important evidence to suppose that this would happen in rats., C. Bavaralle, N. R. Salvetti, G. A. Mira, J. A. Lorente, H. H. Ortega., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2007 Volume:56 | Number:1

Harvested from:

CDK

Metadata only:

false