Ghrelin agonist JMV 1843 increases food intake, body weight and expression of orexigenic neuropeptides in mice

Title:

Ghrelin agonist JMV 1843 increases food intake, body weight and expression of orexigenic neuropeptides in mice

Creator:

Holubová, M., Špolcová, A., Demianová, Z., David Sýkora, Fehrentz, J. A., Martinez, J., Štofková, A., Jana Jurčovičová, Drápalová, J., Zdeňka Lacinová, Martin Haluzík, Železná, B., and Lenka Maletínská

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:8060a2bf-6185-435a-a1e5-5c4ab665068a
uuid:8060a2bf-6185-435a-a1e5-5c4ab665068a

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, GHS-R agonists, JMV 1843, male C57BL/6 mice, food intake, NPY/AgRP, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

Ghrelin and agonists of its re ceptor GHS-R1a are potential substances for the treatment of cachexia. In the present study, we investigated the acute and lo ng-term effects of the GHS-R1a agonist JMV 1843 (H-Aib-DTrp-D-gTrp -CHO) on food intake, body weight and metabolic parameters in lean C57BL/6 male mice. Additionally, we examined stability of JMV 1843 in mouse blood serum. A single subcutaneous injection of JMV 1843 (0.01-10 mg/kg) increased food intake in fed mice in a dose- dependent manner, up to 5-times relative to the saline-treated group (ED 50 =1.94 mg/kg at 250 min). JMV 1843 was stable in mouse serum in vitro for 24 h, but was mostly eliminated from mouse blood after 2 h in vivo . Ten days of treatment with JMV 1843 (subcutaneous administration, 10 or 20 mg/kg/day) significantly increased food intake, body weight and mRNA expression of the orexigenic neuropeptide Y and agouti-related peptide in the medial basal hy pothalamus and decreased the expression of uncoupling protein 1 in brown adipose tissue. Our data suggest that JMV 1843 could have possible future uses in the treatment of cachexia., M. Holubová, ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2013 Volume:62 | Number:4

Harvested from:

CDK

Metadata only:

false